High serum S-100B protein levels within the first 36 hours of acute ischemic stroke predicts high NIHSS scores

Abstract

Aim: The aim of the present study was to evaluate serum levels of S-100B which is an acidic calcium-binding protein within thefirst 36 hours following an acute ischemic stroke and to determine the correlation between S-100B levels and National Institutes ofHealth Stroke Scale (NIHSS) scores.Material and Methods: Fifty patients with ischemic stroke (25 male, 25 female; mean age=64) and 30 healthy volunteers (14 male,16 female; mean age=61) serving as age and sex matched controls were included in this study. Venous blood samples were takenwithin the first 36 hours following the acute stroke. The quantitative determination of S-100B in serum was carried out using anenzyme linked immunosorbent assay.Results: Patients with acute ischemic stroke had significantly higher serum S-100B protein concentrations (42 pg/ml) than thoseof normal controls (31.5 pg/ml) (p