Alteration of saliva and blood ghrelin, obestatin, leptin and weight based on adjuvant chemotherapy treatment in early-stage operated breast cancer patients

Abstract

Aim: To evaluate the weight change and ghrelin, obestatin and leptin levels in operated early stage breast cancer patients receivingadjuvant chemotherapy.Material and Methods: This study was conducted with 22 operated breast cancer patients (examined before and after adjuvantchemotherapy) and 33 BMI-matched two different healthy controls (of 33 healthy controls, 17 BMI-matched control was usedto compare before adjuvant chemotherapy, 16 BMI-matched control was used to compare after adjuvant chemotherapy). Age,anthropometric measurements (weight, BMI, waist circumference), and blood biochemistry were recorded. Blood and salivary totalghrelin, obestatin and leptin levels are measured by using ELISA.Results: The mean ± SD weight (67.2 ± 12.3 and 72.9 ± 11.8 kg., p