Dynamic thiol / disulfide homeostasis in metabolically healthy obese adolescents

Abstract

Aim: This study aim to discuss the possible role of oxidant-antioxidant balance in providing metabolic health in obese adolescentsby determining the oxidant-antioxidant status.Material and Methods: 98 metabolically healthy obese and 75 normal-weight adolescents participated in the study. Obeseindividuals were grouped according to the severity of obesity. Biochemical parameters including thiol/ disulfide homeostasis wereanalyzed. Serum native thiol (SH), total thiol (SH+SS) and disulfide (SS) concentrations were determined using a novel automatedmeasurement method. Disulfide to native thiol ratio (SS/SH), disulfide to total thiol ratio(SS/(SH+SS)), and native thiol to total thiolratio (SH/(SH + SS)) were calculated and were presented as percentage.Results: Native and total thiol levels-as an antioxidative parameter-was significantly higher in obese adolescents compared tohealthy-weight adolescents (p