The role of PET/CT in determining egfr mutation and ALK rearrangement in patients with lung adenocarcinoma

Abstract

Aim: The aim of the present study is to evaluate the role of tumor FDG uptake in a non-invasive method and the use of positronemission tomography / computed tomography (PET/CT) in estimating epidermal growth factor receptor (EGFR) mutations andanaplastic lymphoma kinase (ALK) rearrangements in cases of adenocarcinoma of the lung.Material and Methods: A total of 115 patients with the diagnosis of an adenocarcinoma of the lung that underwent F-18 FDG PET/CTfor staging and whose EGFR mutation and ALK rearrangement status were analyzed were retrospectively analyzed. The associationof the PET parameters (SUVmax, SUVmean, MTV and TLG) of primary tumor with the molecular profile was analyzed.Results: EGFR mutations (EGFR+ group) and ALK rearrangements (ALK+ group) were found in 15 (13%) and 10 (8.7%) of 115 patients;and 90 patients (78.3%) had no EGFR mutation or ALK rearrangement (EGFR/ALK-). EGFR mutations were found to be significantlyhigher among the never-smoked group (p=0.009). No significant association was identified between the SUVmean, MTV and TLGvalues and EGFR mutations; however, patients with a low SUVmax value were found to have a significantly higher rate of EGFRmutation (p=0.034). No statistically significant differences were found between the ALK+ and ALK- group in terms of age, sex,cigarette smoking status, tumor stage, or PET parameters.Conclusion: Our study results suggest that a low SUVmax value in lung adenocarcinomas is associated with EGFR mutation, althoughthe diagnostic efficacy is not high.