Association of adenovirus 36 and gynecomastiadevelopment: A case-control study

Serhat Sirekbasan, Harika Öykü Dinç, Bekir Kocazeybek, Oğuz Çörtük, Suat Sarıbaş, Özgür Pilancı, Melike Keskin, Eda Altan, Nuri Turan, Selçuk Köksal, Sevgi Ergin, Hüseyin Yılmaz, Mehmet Velidedeoğlu

Abstract

Aim: The interaction of various adipokines secreted from adipose tissue during Adenovirus 36 (Ad-36) infection may causegynecomastia. In this study, we aimed to evaluate the association between Ad-36 and gynecomastia development by determiningDNAs and antibodies of Ad-36, adiponectin, leptin, and IL-6 levels. Materials and Methods: Patient and control groups were composed of from 33 male adults with gynecomastia and 15 male adultswith anatomic disorders without gynecomastia, respectively. Serum neutralization assay (SNA) was used for the determination ofAd-36 antibodies and PCR method was used for the determination of Ad-36 DNA. Results: No Ad-36 DNA was found in the breast tissue samples. Ad-36 antibody levels were detected in the patient group withgynecomastia higher than the control group (p0.05). Serum leptin and adiponectin levels were detected to besignificantly different from each other (p