Association between serum gamma-glutamyltransferaselevels and hyperuricemia

Abstract

Aim: Although the the contribution of gamma-glutamyltransferase (GGT) to hyperuricemia (hUA) has been previously shown inliterature, there is not any study showing the contribution of GGT to hUA in a Turkish population. The aim of this study was toinvestigate both the association between GGT and uric acid (UA) and the contribution of GGT to hUA in the Turkish population. Materials and Methods: This retrospective study was conducted in Antalya, Turkey. A total of 14049 subjects (5521 males and 8528females) aged > 40 years were recruited and divided into four subgroups according to serum GGT quartiles. Patient demographicdata and laboratory results of biochemical parameters were obtained from electronic medical records. Linear regression analysiswas applied to GGT quartiles with UA and binary logistic regression analysis was applied to GGT quartiles with hUA. Results: Firstly, serum UA levels were increased across GGT quartiles (p < 0.001). Linear regression models showed GGT in thefourth quartile was strong associated with a 0.22 mmol/L (95% confidence interval (CI) 0.16- 0.29, p = 0.001) increase in UA afteradjustment. Logistic regression analysis revealed that compared with subjects in the lowest GGT quartile, the adjusted oddsratio (OR) for hyperuricemia in the fourth quartile was 2.62 (95% CI 2.27- 3.01, p = 0.001) after adjustment for age, sex, creatinine,total cholesterol (TC), high density lipoprotein (HDL) cholesterol, triglyceride (TG), glycosylated hemoglobin (HbA1c) and alanineaminotransferase (ALT). Conclusions: Serum GGT is closely associated with serum UA and might contributes greatly to hUA.