Platelet to lymphocyte ratio is associated with contrast induced nephropathy after primary percutaneous coronary intervention for ST-elevation myocardial infarction section

Abstract

Aim: Platelet to lyphocyte ratio is a novel inflammatory marker which is correlated with markers such as C-reactive protein andassociated with cardiovascular outcomes in coronary artery disease. Contrast iduced nephropathy is an important complication ofpecutaneous coronary intervention. Association between platelet to lymphocyte ratio and contrast induced nephropathy developmentafter primary percutaneous coronary intervention with a diagnosis of ST-elevation myocardial infarction was evaluated in this study.Material and Methods: Data of 3352 consecutive patients who underwent primary percutaneous coronary intervention for STelevationmyocardial infarction were analysed. Independent predictors of contrast induced nephropathy were investigated withlogistic regression analysis.Results: Patients with contrast induced nephropathy had significantly higher platelet to lymphocyte ratio (150.0 vs 119.1, p=0.001).In multivariate logistic regression analysis platelet to lymphocyte ratio (OR 1.100, 95% CI 1.050-1.130, p=0.033) was found as anindependent predictor of contrast induced nephropathy.Conclusion: Platelet to lymphocyte ratio may have a role to predict contrast induced nephropathy in patients undergoing primarypercutaneous coronary intervention for ST-elevation myocardial infarction.