Kronik Spontan Ürtikerde Siklosporin Tedavisi gle glgili Gözlemlerimiz

Seçil SARAL, Hilayda Karakök GÜNGÖR, AyLenur MADEN, Nihal KUNDAKÇÖ, Beyza DO?ANAY, Lütfü Tat SEMPOZYUMUNDA

Özet

Amaç: ?iddetli seyreden kronik spontan ürtiker vakalarÖnÖn tedavisi güçtür. Bu çalÖLmada kronik ürtiker tedavisinde siklosporinin etkinlik ve güvenilirli?ini ölçmeyi hedefledik. Materyal-Metod: 2005-2016 seneleri arasÖnda klini?imizde tetkik ve tedavi edilen ve ayrÖntÖlÖ fizik muayene bulgularÖ not edilen 20 kronik spontan ürtiker tanÖlÖ hasta çalÖLmaya dâhil edildi. Bulgular: ÇalÖLmaya toplam 20 hasta dâhil edildi. Günlük ürtika pla?Ö sayÖsÖ ve anjioödem ata?Ö sayÖsÖ karLÖlaLtÖrÖldÖ ve her iki parametrenin de anlamlÖ azalma tespit edildi. Tedavinin toplam süresi 27,05 hafta (min: 4, maks:144, ±30,9507) idi. Günlük siklosporin dozlarÖ ortalama 2,2672 mg (min:0,54, maks:3,57 mg) idi. Tedavi altÖnda iki hastada hafif hipertansiyon geliLti ve antihipertansif ajanlarla etkili bir Lekilde tedavi edildi. Bir hastad diplopi geliLti. Üç hastada kreatinin seviyelerinde yükselme tespit edildi. Sonuç: Kronik ürtiker tedavisinde, 27 hafta süre ile günlük ortalama 2,2672 mg siklosporin kullanmanÖn etkili oldu?u tespit edilmiLtir. Yan etki geliLimi açÖsÖndan tüm hastalar takipte tutulmalÖdÖr. Tedavi kesildikten sonra nüks ortalama 9 hafta sonra geliLmiLtir

Abstract

Aim: Treatment of severe chronic autoimmune urticaria is difficult. In this study we aimed to investigate efficacy and safety of cyclosporine in patients with chronic urticaria. Material and Method: Twenty patients with chronic spontaneous urticaria whom detailed physical examination were noted and were treated in our center between 2005 and 2013 were included in this study Results: A total 20 patients were included in this study. Daily wheal number and number of angioedema attacks had been compared and significant reduce in both parameters were detected. Total duration of treatment was mean (min: 4, max: 144) 27,05 (±30,9507 SD, median 18) weeks. Daily cyclosporine dosages were (min: 0,54, max: 3,57), mean 2,2672 (±0,81441SD, median 2,1237). Mild hypertension was detected in two patients under treatment and had been treated with anti hypertensive agents. Dyplopia was developed in 1 patient. We observed elevated creatinine levels in 3 patients. Conclusion: A daily mean dosage of 2,2672 mg of cyclosporine is effective in treatment of chronic urticaria for a duration of 27 weeks. All patients must be followed up closely to monitore adverse events. Recurrence was seen in a mean 9 weeks after cessation of therapy.