Serum Vitamin D Concentrations Among Pregnant Women and Its Influence on the Fetal Anthropometric Measurements

Gebe Kadınlarda Serum D Vitamin Konsantrasyon Düzeyi ve Bunun Fetal Antropometrik Ölçümler Üzerine Etkisi

Melahat YILDIRIM, Halil KARA, Raziye DESDİCİOĞLU, Ali İPEK, Ayşe Filiz AVŞAR YAVUZ, Gülcan DAULETKAZİN

Özet

Amaç: D vitamini yağda çözünen bir vitamin olup güneş ışığından elde edilir. Gebelikte D vitamini eksikliği (DVE) preeklampsi, hipertansiyon, sezaryen doğumlar, preterm doğum gibi kötü gebelik sonuçları ile ilişkili bulunmuştur. Bu çalışmada tekil gebeliği olan kadınlarda DVE ile fetal antropometrik ölçümler, amnion sıvısı anormallikleri ve plasental lokalizasyonu arasında ilişki incelendi. Materyal ve Metot: Bu prospektif çalışma ikinci trimesterde rutin ultrason değerlendirmesi için antenatal kliniğe başvuran 268 gebeden oluşmaktadır. D vitamini ile ilgili kriterlere dayanılarak DVE serum vitamin D

Abstract

Objectives: Vitamin D is a fat-soluble vitamin which comes primarily from exposure to sunlight. Vitamin D deficiency (VDD) in pregnancy is found to be related to adverse pregnancy outcomes including preeclampsia, hypertension, caesarean section, preterm birth, etc. In this current study, we aimed to evaluate the relationship between VDD and fetal anthropometric measurements, amniotic fluid abnormalities, and placental location in pregnant women with singleton pregnancies. Materials and Methods: This prospective study consisted of 268 pregnant women who attended to the antenatal clinics for their routine second trimester prenatal ultrasound screening. VDD is defined as 0.05). Fifty five % of women in VDD group and 46.6% of the cases in NVD group had their placenta located in corpus posterior of the uterus (p= 0.145). Ten out of 190 women in VDD group and 7 out of 78 women in NVD group had polyhydramnios in the study (p= 0.457). Conclusion: The current study failed to demonstrate the relationship between VDD and fetal anthropometric measurements, amniotic fluid abnormalities, and placental location in pregnant women at 20-25 weeks of gestation. Based on the findings in literature, we can assume that other protective mechanisms may play role in preventing fetus from the influence of VDD during the second trimester or fetus has not been affected from the disease, because fetus does not require much calcium and vitamin D due to its small bone mass during this period. The adverse impact of VDD on the fetal bone development can be prevented by appropriate treatment in pregnancy