Carotid artery intima-media thickness in pediatric type 1 diabetic patients

Abstract

Objective: To compare the carotid artery intima-media thickness in pediatric type 1 diabetic patients with that in healthy control subjects matched for age, sex, height, weight, body mass index (BMI) and waist circumference.Methods: Fifty diabetic patients and forty-five control subjects were enrolled into this observational, cross-sectional, controlled study. Carotid artery intima-media thickness (cIMT), flow-mediated dilation (FMD) and carotid stiffness index were measured by using a carotid Doppler and real-time ultrasound. Student's t, chi-square and Kolmogorov-Smirnov tests and Pearson's correlation coefficient were used for the statistical analysis.Results: There were no significant differences in the groups for age, sex, height, weight, BMI and waist circumference (mean age 12.10±2.02 vs. 11.49±1.90 years, weight 41.14±11.28 vs. 40.88±11.68 kg, height 149.78±20.3 vs. 145.62±20.14 cm, BMI 18.49±2.64 vs. 18.26±2.59 kg/m2, waist circumference 69.72±8.6 vs. 66.05±7.47 cm, respectively). A significantly higher cIMT was found in the patients with type 1 diabetes (0.49±0.05 vs. 0.44±0.03 mm; p