The Relationship Between MaternalAntidepressants and Neonatal Hypoglycemia:A Systematic Review

Abstract

The aim of the article is to review systematically current researches investigating therelationship between intrauterine exposure to antidepressants and neonatal hypoglyce mia. This paper included studies published in electronic databases from January 2005 toJuly 2020. The searched keywords were as follows: antidepressants, pregnancy, selectiveserotonin reuptake inhibitors (SSRIs), citalopram, fluoxetine, paroxetine, escitalopram,sertraline, fluvoxamine, selective serotonin-norepinephrine reuptake inhibitors (SNRIs),venlafaxine, tricyclic antidepressants (TCAs), neonatal outcomes, neonatal hypoglyce mia, imipramine, clomipramine, amitriptyline, bupropion, trazodone, and mirtazapine.This review examined 10 relevant studies. The odds ratio/risk ratio reported in the studieswere 1.33-1.73 for any antidepressant, 1.30-1.35 for SSRI, 1.42-2.11 for SNRI, and 2.07 forTCAs. The risk of neonatal hypoglycemia in infants exposed to maternal TCAs appears tobe slightly higher compared to infants exposed to maternal SSRIs. Data from current stud ies consistently show that exposure to maternal antidepressants during pregnancy maybe related to increased risk of neonatal hypoglycemia in infants.