Dergiler / Türk Göğüs Kalp Damar Cerrahisi Dergisi / 2011 / Cilt: 19 - Sayı: 3
Prognostic importance of serum CRP, prealbumin, and transferrin levels in patients with advanced stage esophageal cancer
- Sayfa
- 384–390
- DOI
- —
Özet
Amaç: Bu çalışmada stent takılarak tedavi edilen ileri evre özofagus kanserli hastalarda serum C-reaktif protein (CRP), prealbumin ve transferrin düzeylerinin prognostik değeri araştırıldı. Çalışma planı: Temmuz 2007 ve Aralık 2008 tarihleri arasında gerçekleştirilen prospektif randomize bir çalışmada lokal olarak ilerlemiş hastalık veya uzak organ metastazı nedeniyle stent takılarak tedavi edilen ardışık 61 hastada, stent takılmadan 1-3 gün önce serum CRP, prealbumin ve transferrin düzeyleri çalışıldı. Tüm hastalar ölünceye kadar takip edildi. Bulgular: Stent tüm hastalarda başarı ile takılarak oral alım tekrar sağlandı. İşleme bağlı mortalite gözlenmedi. Hastaların ortalama sağkalım süresi 164.3±120.3 gün (dağılım 15-450 gün) idi. Serum CRP seviyesi ≥10 mg/L olan hastalarda (n=38) ortalama sağkalım 103.2±82.3 gün iken serum CRP seviyesi <10 mg/L olan hastalarda (n=23) ortalama sağkalım 265.4±121.2 gün idi. Serum prealbumin seviyesi ≥15 mg/L olan hastalarda (n=28) ortalama sağkalım 237.5±132.7 gün iken serum prealbumin seviyesi <15 mg/L olan hastalarda (n=33) ortalama sağkalım 102.3±79.6 gün idi. Serum transferrin seviyesi ≥200 mg/L olan hastalarda (n=25) ortalama sağkalım 211.6±130.2 gün iken serum transferrin seviyesi <200 mg/L olan hastalarda (n=36) ortalama sağkalım 131.5±113.8 gün idi. Referans serum CRP, prealbumin ve transferrin seviyelerinin sağkalımla ilişkisi istatistiksel olarak anlamlı idi (sırasıyla p<0.001, p<0.001 ve p=0.003). Sonuç: İleri evre özofagus kanserli hastalarda özofageal stent uygulamasından önce serum CRP, prealbumin ve transferrin düzeyleri kolaylıkla saptanabilir ve hastaların prognozları hakkında fikir elde edilebilir.
Abstract
Background: This study investigated the prognostic value of serum C-reactive protein (CRP), prealbumin, and transferrin levels in patients with advanced stage esophageal cancers treated with stent placement. Methods: In a prospective, randomized study conducted between July 2007 and December 2008, serum CRP, prealbumin, and transferrin levels were determined 1-3 days prior to stent placement in 61 consecutive patients who underwent stent placement due to locally advanced disease or distant organ metastasis. All patients were followed until death. Results: The stent was successfully placed in all patients and oral intake was restored. There was no procedure-related mortality. The mean survival period of the patients was 164.3±120.3 days (range 15 to 450 days). Whereas the mean survival period was 103.2±82.3 days in patients with a serum CRP level ≥10 mg/L (n=38), it was 265.4±121.2 days in patients with a serum CRP level <10 mg/L (n=23). While the mean survival period was 237.5±132.7 days in patients with a serum prealbumin level ≥15 mg/L (n=28), the mean survival period was 102.3±79.6 days in patients with a serum prealbumin level <15 mg/L (n=33). The mean survival period was 211.6±130.2 days in patients with a serum transferrin level ≥200 mg/L (n=25) while the mean survival period was 131.5±113.8 days in patients with a serum transferrin level <200 mg/L (n=36). The relationship between serum CRP, prealbumin, and transferrin levels in reference to survival was statistically significant (p<0.001, p<0.001, and p=0.003, respectively). Conclusion: Serum CRP, prealbumin, and transferrin levels can easily be measured prior to esophageal stent placement in patients with advanced stage esophageal cancer and the results may give an idea on the prognosis of the patients.