Küçük hücreli dışı akciğer kanserinde signal peptide-Complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1’in serum ve doku örnekleri üzerindeki tanısal değeri

Diagnostic value of signal peptide-Complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 on serum and tissue samples in non-small cell lung cancer

Özet

Amaç: Bu çalışmada küçük hücreli dışı akciğer kanseri hastalarında akciğer kanserinin türü, evresi ve yaygınlığı ile serum ve akciğer dokularındaki signal peptide-Complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 düzeyleri arasında ilişki olup olmadığı ve malign veya benign hastalıklı hastaların signal peptide -Complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 düzeyleri arasında farklılık olup olmadığı araştırıldı. Çalışma planı: Çalışmaya tanı veya tedavi amacıyla ameliyat edilen 25 rezektabl küçük hücreli dışı akciğer kanseri hastası (21 erkek, 4 kadın; ort. yaş 64.6±9.4 yıl; dağılım, 41-79 yıl) (grup 1), 15 unrezektabl küçük hücreli dışı akciğer kanseri hastası (10 erkek 5 kadın; ort. yaş 61.8±9.6 yıl; dağılım, 48 -82 yıl) (grup 2) ve kanser dışı nedenlerle ameliyat edilen 15 hasta (14 erkek, 1 kadın; ort. yaş 42.5±19.5 yıl; dağılım, 18 -76 yıl) (grup 3; kontrol grubu) olmak üzere üç gruba ayrılan 55 denek (45 erkek, 10 kadın; ort. yaş 57.8±15.9 yıl; dağılım 18-82 yıl) dahil edildi. Bulgular: Grup 1 ve 2’de ameliyat öncesi serum signal peptide-Complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 düzeyleri kontrol grubuna göre daha yüksek idi (p=0.045). Grup 2’de serum signal peptide-Complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 düzeyleri diğer iki gruba göre anlamlı şekilde daha yüksek idi (p=0.008). Küçük hücreli dışı akciğer kanseri hastalarında doku örneklerindeki signal peptide-Complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain -containing protein 1 düzeyleri anlamlı şekilde daha yüksekti ve prognostik öneme sahipti; öyle ki, doku signal peptide-Complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain- containing protein 1 konsantrasyonundaki 1 ng/mL’lik bir artış ölüm riskinde 1.4 kat artışa neden oldu (p=0.009). Sonuç: Serum ve tümör dokusundaki signal peptide-Complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 konsantrasyonu küçük hücreli dışı akciğer kanseri hastalarında tanı ve prognozu belirlemede önemli bir biyobelirteç olabilir.

Abstract

Background: This study aims to investigate whether there is any relationship between the type, stage and the extensiveness of lung cancer and levels of signal peptide- Complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 in serum and lung tissues of non-small cell lung cancer patients and also whether there is any difference in signal peptide-Complement C1r/C1s, Uegf, and Bmp1- epidermal growth factor domain- containing protein 1 levels of patients with malignant or benign diseases.Methods: The study included 55 subjects (45 males, 10 females; mean age 57.8±15.9 years; range 18 to 82 years) who were separated into three groups as 25 resectable non-small cell lung cancer patients (21 males, 4 females; mean age 64.6±9.4 years; range, 41 to 79 years) who were operated with the purpose of diagnosis and treatment (group 1), 15 unresectable non- small cell lung cancer patients (10 males, 5 females; mean age 61.8±9.6 years; range, 48 to 82 years) (group 2), and 15 patients (14 males, 1 females; mean age 42.5±19.5 years; range, 18 to 76 years) who were operated with non-cancer related reasons (group 3; control group).Results: Preoperative serum signal peptide-Complement C1r/C1s, Uegf, and Bmp1- epidermal growth factor domain-containing protein 1 levels in groups 1 and 2 were significantly higher compared to control group (p=0.045). Serum signal peptide-Complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 levels in group 2 were significantly higher compared to the other two groups (p=0.008). Levels of signal peptide-Complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 in tissue samples were significantly higher in patients with non-small cell lung cancer and yielded a prognostic importance such that a 1 ng/mL rise in tissue signal peptide-Complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 concentration caused a 1.4 fold increase in death risk (p=0.009).Conclusion: Concentration of signal peptide-Complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 in serum and tumor tissue may be an important biomarker in determining the diagnosis and prognosisin non-small cell lung cancer patients.