Association between the Serum Metabolic Profile and Lung Function in Chronic Obstructive Pulmonary Disease

Özet

OBJECTIVES: Although dietary patterns are known to modulate disease severity in patients with chronic obstructive pulmonary disease (COPD),the relationship between the circulating lipid profile and lung function in COPD has not been studied extensively.MATERIAL AND METHODS: There were 43 COPD patients with a history of smoking and 39 patients with a history of biomass fuel exposurerecruited in this study, along with 43 age-matched healthy controls. All participants underwent complete lung function profiling, and their glu-cose and lipid profiles were measured. The association between the metabolic profile and lung function was assessed using the Spearman’srank-order correlation coefficient.RESULTS: 52.4% of the COPD patients were smokers compared to the healthy group (46.5%). We found an inverse correlation betweentriglyceride and functional residual capacity (p=-0.21, p=0.05) and a positive association between serum cholesterol and overall airwayresistance (R5) (p=0.24, p=0.04) and central airway resistance (R20) (p=0.32, p=0.004). Low-density lipoprotein (LDL) cholesterol andhigh-density lipoprotein (HDL) ratio and LDL/HDL ratio were also found to correlate with R5 (p=0.25, 0.23, and 0.22, respectively) andR20 (p=0.31, 0.24, and 0.24, respectively). No significant association was observed between other metabolites and either spirometricor plethysmographic lung function indices.CONCLUSION: High serum triglyceride and cholesterol may increase the resistance in the airways, which may lead to increased airwayobstruction. Therefore, monitoring of lipid profile should be considered in the diagnosis and management of COPD.