The Use of Inhaled Corticosteroids to Prevent Acute Exacerbations of COPD: A Pro/Con Debate

Özet

The use of inhaled corticosteroids (ICS) has been accepted as standard practice following early landmark studies. These demonstrated areduction in the risk of acute exacerbations of COPD (AECOPD). However, these studies were performed at a time when other therapieswere not available and now our standards of care have changed. Other data has emerged which have also raised concerns as to anincrease in the incidence of pneumonia in COPD patients taking inhaled corticosteroids. It is thus timely to evaluate the evidence. Wepresent the two sides of this debate and consider the evidence both for the use of ICS as the best therapy to reduce the risk of AECOPDand also the evidence for the use of bronchodilators as a more effective and safer alternative. It is clear that as we approach an age ofpersonalised medicine taking a “one size fits all” approach is both intellectually and medically wrong. We present the evidence that willhelp clinicians make better decisions for each of their patients.