Data to assist in the determination of biochemistry test ranges to assess hemodialysis efficacy in patients with chronic renal failure

Özet

Objectives: Reference intervals are usually defined based on blood samples from healthy subjects and specific refer ence ranges for patients on hemodialysis (HD) are not currently available. The aim of the study was to establish expect ed ranges of biochemical analytes before and after HD for patients with chronic renal failure (CRF). Methods: The findings of the 4 most recent quarterly check-ups of 684 patients (233 women and 451 men; age 18-95 years) treated with HD in several dialysis units attached to a single laboratory were studied. Biochemical analytes were measured using fully automated Roche Cobas C 501 or C 701 analyzers (Roche Diagnostics, Basel, Switzerland). Expect ed ranges were set according to International Federation of Clinical Chemistry and Clinical and Laboratory Standards Institute guidelines using the nonparametric method. Results: Compared with pre-HD values, beta-2 microglobulin (β2m), chloride, creatinine, phosphate, potassium, and urea concentrations were lower post-HD (p 10%) in the creatinine level between individuals under and over 60 years of age (p<0.0001). Conclusion: The establishment of specific ranges for dialysis patients could contribute to finding specific thresholds to monitor the effectiveness of HD.