Dergiler / Turkish Journal of Hematology / 2009 / Cilt: 26 - Sayı: 3
Usage of U7 snRNA in gene therapy of hemoglobin S disorder - is it feasible?
- Sayfa
- 159–159
- DOI
- —
Özet
OBJECTIVE: OBJECTIVE: Hemoglobin (Hb) S disorder [beta6(A3)Glu-->Val, GAG >GTG] is an important hemoglobinopathy with the highest endemicity in Africa. METHODS: METHODS: Here, the author performs a basic bioinformatics gene ontology study to assess the effect of co-expression between nucleic acid sequence for human Hb S beta globin chain and U7.623. RESULTS: : According to this study, the analytical results show that fully recovery of hemoglobin in both function and biological process can be got. CONCLUSION: CONCLUSION: Here, the author proposed that U7 snRNA might be a probable tool for treatment by gene therapy approach in Hb S disorder.
Abstract
OBJECTIVE: OBJECTIVE: Hemoglobin (Hb) S disorder [beta6(A3)Glu-->Val, GAG >GTG] is an important hemoglobinopathy with the highest endemicity in Africa. METHODS: METHODS: Here, the author performs a basic bioinformatics gene ontology study to assess the effect of co-expression between nucleic acid sequence for human Hb S beta globin chain and U7.623. RESULTS: : According to this study, the analytical results show that fully recovery of hemoglobin in both function and biological process can be got. CONCLUSION: CONCLUSION: Here, the author proposed that U7 snRNA might be a probable tool for treatment by gene therapy approach in Hb S disorder.