Dergiler / Turkish Journal of Hematology / 2007 / Cilt: 24 - Sayı: 3
Thrombocytosis in the neonatal intensive care unit: Experience at a single center
- Sayfa
- 110–116
- DOI
- —
Özet
Bu yenidoğânlârın ortalama trombosit sayıları 579.7 ± 111.5 (451-936) x 109A idi. Trombösitozla birlikte bulunan tıbbi durumlar şöyleydi: %73.7 anemi, %56.2 yüksek riskli gebelik, 9651.7 premâtürite, %37.1 infeksiyonlar, %22.7 antenatal ilaç kullanımı, %20.2 indirekt hİperbilirubinemi, %14.6 kardlyâk hâstaliklar, %14.6 respiratuar distres hastalıkları, %13.5 hipoksi hikayesi, %İ2.4 ameliyat, %3.4 herrioraji. Olguların çoğunda aynı yenidoğahda birden fazla risk faktörü buiundu. Trombosİtoza bağiı hemörajik bir kompiikasyon görülmezken, sâdece bir yenidöğanda intestinal lîıalrotâsyöna bağlı portal ven trömbozu mevcuttu. Sonuç olarak, yenidoğan trombositozuyla birlikte bulunan tıbbi durumlar ve risk faktörlerinin çocukluk yaş grubundan farkli olduğu bulundu.
Abstract
Although thrombocytosis is frequently detected in newborns, few reports have focused on its risk factors. This report documents the characteristics of 89 neonates with thrombocytosis followed up in a neonatal intensive care unit (NICU). We reviewed the patients' medical and laboratory records retrospectively to determine the associated conditions and risk factors for neonatal thrombocytosis, and complications related to thrombocytosis- We also discussed the differences of neonatal thrombocytosis from that of childhood in the light of literature. The mean platelet count of these newborns was 579,7 ±111.5 (451-936) x 109/L Associated conditions included anemia (73.7%), high-risk pregnancies (56. %), prematurity (51.7%), infections (37.1%), antenatal drug use (22.7%), indirect hyperbilirubinemia (20.2%), cardiac disorders (14.6%), respiratory distress syndrome (14.6%), history of hypoxia (13.5%), surgery (12.4%), and hemorrhage (3.4%). In most cases, more than one risk factor for thrombocytosis existed in the same newborn. No hemorrhagic complications related to thrombocytosis were observed; however, 1 newborn had portal vein thrombosis associated with intestinal malrotation. In summary, risk factors and associated conditions for thrombocytosis in newborns differed from those in children. In light of associated disorders, the mechanism of thrombocytosis in newborns may differ from that of childhood thrombocytosis.