Asymptomatic intracranial hemorrhage in a newborn with congenital factor VII deficiency and successful treatment with recombinant activated factor VII

Özet

Intracranial hemorrhage is considered the most common cause of death innewborns with congenital factor VII (FVII) deficiency. Recombinant activatedFVII (rFVIIa) provides specific replacement therapy, however there is limitedexperience with its neonatal use. We describe our experience about thetreatment of intracranial hemorrhage in a newborn with congenital FVIIdeficiency and emphasize the importance of imaging in asymptomatic patients.She presented with ecchymoses on her skin, no other pathological clinical signs,prolonged PT, normal PTT and FVII activity of 2%. Intracranial hemorrhagewas diagnosed while screening for internal bleedings. Treatment with rFVIIaresulted in stabilization and regression of the hematoma.