Plasma lipoxin A4 levels in childhood chronic spontaneous urticaria

Özet

Chronic spontaneous urticaria (CSU) is an idiopathic inflammatory disorder.Despite great research progress, the pathogenesis of the disease is still notfully understood. Lipoxins (LXs) are autacoid lipid metabolites that are thefirst discovered members of a new genus named called “specialized proresolvingmediators”. In this study, we aimed to investigate the possible role of LXA4in the pathogenesis of CSU.Forty-two children with CSU and 25 healthy children were enrolled in thestudy. The demographic and clinical features of patients were evaluated,autologous serum skin tests (ASSTs), and routine laboratory assessmentswere performed. Disease activity was determined using the urticaria activityscore. An enzyme-linked immunosorbent assay was used to evaluate LXA4plasma levels.The median value of plasma LXA4 was found to be 60.8 ng/ml (interquartilerange, 48.1–71.8) in CSU patients and 137.4 ng/ml (121.4–150.8) in thecontrol group. The difference between the groups was statistically significant(p<0.001). Additionally, the median plasma LXA4 levels in the ASST-positivepatients were significantly reduced compared to the ASST-negative ones (45.8[36.7–67.6] versus 63.8 [58.3–78.9] ng/ml, respectively, p <0.05).Our results showed that diminished LXA4 biosynthesis may be a critical partof CSU pathogenesis in children, especially in patients with an autoimmunecomponent.