Expression of the Toll-like receptors 2 gene as a genetic determinant of the formation of newborns multiple organ failure syndrome

Özet

Activation of the humoral immune response in newborns’ multiple organfailure syndrome is associated with the production of interleukin-1β, whichis recognized via Toll-like receptors 2 (TLR2). The aim of this study wasto determine the role of expression of the Toll-like receptors 2 gene in thepathogenesis of newborns with multiple organ failure syndrome.A prospective observational cohort study of 149 newborns was conducted.The main group (n = 113) were newborns with multiple organ failuresyndrome, whereas the comparison group (n = 36) was newborns withoutthis syndrome. The study included analysis of the expression of the TLR2gene and its comparison with the concentration of interleukin-1β, peripheralblood lymphocyte count and clinical signs of the course of the disease.It was found that the population risk of reducing TLR2 expression was79.33% in the main group, and 27.62% in the comparison group. Increasingthe expression of the gene TLR2 in newborns leads to an increase in theconcentration of interleukin-1β, an increase in the level of peripheral bloodlymphocytes and is associated with the formation of microbial loci. Expressionreduction of the TLR2 gene may lead to the development of multiple organfailure syndrome, systemic inflammatory response syndrome, increase in thenumber of affected organs, increased frequency of involvement in the immunesystem, and the need for aggressive respiratory therapy.