Diagnostic accuracy of glycoproteins in the assessment of liver fibrosis: A comparison between laminin, fibronectin, and hyaluronic acid

Özet

Background/Aims: Liver fibrosis is a chronic liver injury affecting numerous individuals in the world, and efforts have been exercised forintroducing a non-invasive method to evaluate the stages of liver fibrosis, which can be used instead of invasive methods, such as a liverbiopsy. Various glycoproteins have been suggested by many investigators as indicators of liver fibrosis. This study aimed to comparethe diagnostic accuracy of serum laminin, fibronectin, and hyaluronic acid levels in the assessment of liver fibrosis for discriminatingpatients from healthy subjects.Materials and Methods: We searched the English language literature to identify relevant studies regarding the role of glycoproteins inthe assessment of liver fibrosis, using the following electronic databases: Medline, PubMed central, web of knowledge (ISI), Scopus, Google scholar, Springer, and Science Direct from 1981 to 2016. The key words used for searching were “glycoproteins”, “laminin”, “hyaluronicacid”, “fibronectin”, “diagnostic accuracy”, “assessment”, “liver fibrosis”, “cirrhosis”, “liver biopsy”, “grading”, and “staging”. The statisticaldata relevant for the diagnostic accuracy were extracted and analyzed using the summary receiver operating characteristic curves.Results: The diagnostic accuracy among the glycoproteins involved in this study were compared, and the area under curves for serumlevels of laminin, hyaluronic acid, and fibronectin, as indicators of diagnostic accuracy, were 0.89, 0.82, and 0.73, respectively.Conclusion: It can be concluded that when liver biopsy is contraindicated, the serum levels of laminin, hyaluronic acid, and fibronectincan be considered screening tests as well as additional clinically useful tools for the evaluation of liver fibrosis.