Validity and reliability of the Quality of Life in Reflux and Dyspepsia (QoLRAD) questionnaire in patients with gastroesophageal reflux disease for the Turkish population

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Background/Aims: Gastroesophageal reflux disease negatively affects quality of life. The aim is to improve quality of life because ofhigh recurrence rate. There is a strong need for patient-reported outcome measures. The present study aimed to evaluate the validityand reliability of the Quality of Life in Reflux and Dyspepsia Questionnaire (QoLRAD) to adopt it into Turkish.Materials and Methods: A total of 142 patients with complaints of heartburn or regurgitation once a week or commonly diagnosed with24-hour intraesophageal impedance-pH monitoring and/or upper gastrointestinal endoscopy were included in this study. Sociodemographic Data Collection Form, QoLRAD-TR, and Short Form-36 (SF-36) were applied to patients who were off proton pump inhibitors.Results: The Cronbach’s alpha coefficient value of the questionnaire was 0.97, and the intraclass correlation coefficient (ICC) valueof the result of test-retest method was between 0.97 (Vitality) and 0.99 (Eating/Drinking Disorders). There was a positive correlationbetween all subdomains of QoLRAD-TR and SF-36 scales. The lowest correlation (0.10) was between Emotional Distress and Role-emotional Limitations, and the highest (0.34) was between Energy and Vitality.Conclusion: The QoLRAD test measuring quality of life, except some subdomains in our study that we performed on patients diagnosedwith GERD, was found to be valid and reliable.