Fall of another myth for colon cancer: Duration of symptoms does not differ between right- or left-sided colon cancers

Özet

Background/Aims: Patients with colorectal cancer continue to present with relatively advanced tumors that are associated with pooroncological outcomes. The aim of the present study was to assess the association between localization, symptom duration, and tumorstage.Materials and Methods: A prospective, multicenter cohort study was conducted on patients newly diagnosed with a histologically proven colorectal adenocarcinoma. Standardized questionnaire-interviews were performed. Data were collected on principal presentingsymptoms, duration of symptoms (time to first presentation to a doctor and time to diagnosis) and treatment, diagnostic procedures,tumor site, and stage of the tumor (tumor, node, and metastasis (TNM)).Results: A total of 1795 patients with colorectal cancer were interviewed (mean age: 60.76±13.50 years, male patients: 1057, patientsaged >50 years: 1444, colon/rectal cancer: 899/850, right side/left side: 383/1250, stage 0-1-2/stage 3-4: 746/923). No statisticallysignificant correlations were found between duration of symptoms and either tumor site or stage. Principal presenting symptoms weresignificantly associated with left colon cancer. Patients who had “anemia,” “change in bowel habits,” “anal pruritus or discharge,” “weightloss,” and “tumor in right colon” had a significantly longer symptom time.Conclusion: Symptom duration is not associated with localization, nor is the tumor stage. Diagnosis of colorectal cancer at an earlierstage may be best achieved by screening of the population.