Immunoglobulin G4-related immune responses to common food antigens in patients with ulcerative colitis and Crohn’s disease

Özet

Background/Aims: It is unclear whether IgG4-related immune responses to food can play a role in the pathogenesis of inflammatorybowel disease (IBD). The aim of the present study was to investigate the serum levels of IgG4 to common food antigens in patients withulcerative colitis (UC), Crohn’s disease (CD), and healthy controls.Materials and Methods: Thirty-six patients with CD (n=12) or UC (n=24) and 36 sex- and age-matched healthy individuals (mean age,49 years) participated in the study. Serum levels of IgG4 to 90 common food antigens were measured. The number of subjects withpositivity, defined by cut-off values ≥0.7 U/mL, was compared.Results: Serum titers of IgG4 to salmon, onion, shrimp, cuttlefish, eel, millet, gluten, soybean, and coconut in patients with IBD weresignificantly or tended to be higher than those in the control group. Serum levels of IgG4 to salmon, millet, and onion in patients with CDwere significantly or tended to be higher than those in the control group. Serum titers of IgG4 to cuttlefish and onion in patients withUC tended to be higher than those in the control group. The number of subjects with positivity to cod, tuna, mackerel, oat, pea, peanut,and coconut was significantly higher in patients with CD than in healthy controls. The number of subjects with positivity to kiwi andcuttlefish was significantly higher in patients with UC than in controls.Conclusion: Patients with IBD shows higher serum levels of IgG4 to diverse food antigens. Patients with CD present IgG4-related immune reactions to more foods than patients with UC.