Dergiler / Turkish Journal of Medical Sciences / 2013 / Cilt: 43 - Sayı: 4
Comparison of the protective effects of desflurane and propofol anesthesia in rats: a hepatic ischemia-reperfusion injury model
- Sayfa
- 592–598
- DOI
- —
Özet
It is known that desflurane and propofol protect liver tissue via different mechanisms. The aim of this study was to compare the protective effects of these 2 agents against hepatic ischemia-reperfusion injury. Materials and methods: Rats were randomly divided into 2 groups: ischemia and ischemia-reperfusion. Each group was further divided into 3 subgroups: ketamine, desflurane, and propofol. Thirty minutes after anesthetics were administered, the rats were subjected to 45 min of hepatic ischemia and 4 h of reperfusion. Blood samples and liver tissues were obtained in order to assess serum tumor necrosis factor alpha (TNF-a), interleukin-1b (IL-1b), and malondialdehyde levels and for histologic examination. Results: The postischemic serum IL-1b levels were significantly higher with propofol than with ketamine (P = 0.014). In the postischemic period, in the ischemia-desflurane group, TNF-a levels were significantly lower than in the ischemia-propofol (P = 0.009). The number of polymorphonuclear leukocytes was the lowest in the ketamine group in the postischemic period (P < 0.01). Conclusion: In order to reach a definitive judgment, studies with a larger number of subjects are necessary.
Abstract
It is known that desflurane and propofol protect liver tissue via different mechanisms. The aim of this study was to compare the protective effects of these 2 agents against hepatic ischemia-reperfusion injury. Materials and methods: Rats were randomly divided into 2 groups: ischemia and ischemia-reperfusion. Each group was further divided into 3 subgroups: ketamine, desflurane, and propofol. Thirty minutes after anesthetics were administered, the rats were subjected to 45 min of hepatic ischemia and 4 h of reperfusion. Blood samples and liver tissues were obtained in order to assess serum tumor necrosis factor alpha (TNF-a), interleukin-1b (IL-1b), and malondialdehyde levels and for histologic examination. Results: The postischemic serum IL-1b levels were significantly higher with propofol than with ketamine (P = 0.014). In the postischemic period, in the ischemia-desflurane group, TNF-a levels were significantly lower than in the ischemia-propofol (P = 0.009). The number of polymorphonuclear leukocytes was the lowest in the ketamine group in the postischemic period (P < 0.01). Conclusion: In order to reach a definitive judgment, studies with a larger number of subjects are necessary.