The Effect of Phenyramidol on Neural Development in Early Chicken Embryo Model

Özet

AIM: To investigate the effects of Phenyramidol (Phe) on neural development in an early chicken embryo model.MATERIAL and METHODS: Sixty fertile non-pathogenic Super Nick eggs were incubated for 24 hours (h) and divided into fourgroups of 15 eggs each. Phe was administrated through the sub-blastoderm, and the eggs were incubated for another 24 h. All eggswere opened after 48 h of incubation, and the embryos were evaluated morphologically and histopathologically.RESULTS: In Group 1 (control group), none exhibited neural tube defects (NTDs) (0%), 1 (6.6%) was undeveloped; in Group 2 (lowdosages), 1 did not develop (6.6%); in Group 3 (normal dosages), 2 (13.4%) had NTDs, 1 (6.6%) was undeveloped; in Group 4 (highdosages), 5 (33.3%) had NTDs, 2 (13.3%) were undeveloped.CONCLUSION: In light of the results, it was determined that the use of increasing doses of Phe led to defects in midline closure inearly chicken embryos. This is the first report in the literature on Phe used in an early chicken embryo model.