Modified Frailty Index and Body Mass Index as Predictors of Adverse Surgical Outcomes in Degenerative Spinal Disease

Özet

AIM: To reveal the potential relationships and interactive effects between frailty and body weight and adverse surgical outcomesfor degenerative spinal disease.MATERIAL and METHODS: Patients who underwent open surgery for degenerative spinal disease in our hospital were included.Data on the patients and disease variables was obtained. The primary independent variables included body mass index (BMI) andmodified Frailty Index (mFI). The primary outcome was the Clavien-Dindo complications classification. After univariate analyses,multinomial and ordinal regression analyses were applied with the Clavien-Dindo complications grade as the dependent variable andthe potential risk factors for complications as independent variables, respectively, to determine the potential interactive relationshipbetween the two primary risk factors and their impact on postoperative complications grading.RESULTS: A total of 1970 patients were included in the study. The results showed that “underweight” could significantly increasethe odds ratios of “prefrail” and “frail” at the same time; however, “obese” could only increase the odds ratio of “frail”. The“underweight”, “obese”, “prefrail” and “frail” subgroups could significantly increase the grading of postoperative complications,respectively. If mFI and BMI were combined as an interactive variable, the results showed that in the “underweight” and “normalweight” subgroups, both “prefrail” and “frail” could significantly increase the grading of postoperative complications; however,in the “overweight” and “obese” subgroups, only the “overweight/frail”, “obese/non-frail” and “obese/frail” subgroups displayedsignificantly increased grading of postoperative complications.CONCLUSION: The present results serve to stratify susceptible patients with easily identified risk factors preoperatively.