Magnesium Acetyl Taurate Prevents Tissue Damage and Deterioration of Prosocial Behavior Related with Vasopressin Levels in Traumatic Brain Injured Rats

Özet

AIM: To investigate the effects of different magnesium forms on tissue damage, cognitive and emotional behavioural impairmentafter mild traumatic brain injury (TBI).MATERIAL and METHODS: Rats were divided into 5 groups (control, trauma, magnesium sulphate, magnesium citrate, magnesiumacetyl taurate) and following head trauma, empathy-like behaviour, anxiety-like behaviour (elevated plus maze and open field tests),and depression (forced swim test) were measured. The rats were then sacrificed 12 days later. Oxytocin, vasopressin and receptorslevels in the amygdala and prefrontal cortex regions were measured. Histopathological damage (with haematoxylin-eosin staining)and apoptosis (with caspase-3 immunohistochemistry) was evaluated.RESULTS: Following head trauma, anxiety-like behaviour and depression tests did not change; empathy-like behaviour deterioratedon the 3rd day and improved gradually on the 6th and 12th days. Oxytocin, vasopressin and vasopressin v1b receptor levels decreasedin the amygdala; morphological damage and apoptosis were significant. Magnesium acetyl taurate effectively amelioratedhistopathological deteriorations and improved vasopressin and v1b receptor levels in the amygdala. Transient deterioration ofempathy-like behaviour was impeded only in magnesium taurate treatment.CONCLUSION: Magnesium acetyl taurate can be a promising candidate agent to prevent structural and functional damage intraumatic brain injury.