The Analysis of Safety and Effectiveness Using Allograft in the Treatment of Spinal Tuberculosis-A Multicenter Retrospective Study

Özet

AIM: To evaluate the clinical efficacy and fusion characteristics of allografts in spinal tuberculosis (TB).MATERIAL and METHODS: The research reviewed 1196 patients with spinal tuberculosis who received treatment at six hospitalsfrom January 2000 to January 2016. A total of 623 patients who had spinal tuberculosis were included in the study. All patientsunderwent debridement, decompression, allograft bone grafting, and instrumentation. Postoperative treatment consisted of acombination of anti-TB drug treatment for 18 months and brace fixed braking for 3–9 months. Clinical outcome, laboratory indexes,and radiological results were analysed.RESULTS: The average follow-up time was 34.1 months (12–60 months). Pain was relieved postoperatively in all cases, and 87.8%of patients were painless at the final follow-up. The erythrocyte sedimentation rate (ESR) significantly decreased and returned tonormal at the final follow-up. The fusion rate of allografts was 30.2% and 98.4% at the 9- and 12-month follow-ups, respectively. Atthe final follow-up, the fusion rate was 100%.CONCLUSION: The application of allografts in the surgical management of spinal tuberculosis is safe and effective. Allografts canreplace autografts in surgeries for spinal tuberculosis.