The Effect of Indicators of Systemic Inflammatory Response on Survival in Glioblastoma Multiforme

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AIM: To evaluate the prognostic value of preoperative neutrophil-to-lymphocyte ratio and platelet-lymphocyte ratio in glioblastomamultiforme patients.MATERIAL and METHODS: A total of 75 patients retrospectively analysed. The complete blood count of the patients was analysedbefore surgery. In our study, cut-off values for PLR 150 (platelet-lymphocyte ratio) and NLR 4 (neutrophil-to-lymphocyte ratio) werefound to be significant by creating the ROC curve. Overall survival (OS) was calculated from surgery to death or the last contact.Progression-free survival (PFS) was calculated from surgery to progression. The last follow-up was November 2018.RESULTS: The median OS was significantly shorter in PLR>150 patients (p=0.005; 10 vs 17 months). And the median OS wassignificantly shorter in NLR>4 patients too (p=0.010; 11 vs 17 months). In multivariate analysis, Karnofsky performance score 4 (HR:2.14, 95% CI:1.11-4.14; p=0.023) were statistically significant for OS were found to be independentprognostic factor.CONCLUSION: The presence of 70 4,70<KPS, type of surgical resection were independent prognostic factors that negatively affect for the OS.