Dergiler / Turkish Journal of Pharmaceutical Sciences / 2010 / Cilt: 7 - Sayı: 2
Molecular analysis of mycobacterial DNA in some cases of sarcoidosis: Correlation with clinical course and 10 years’ observation
- Sayfa
- 189–195
- DOI
- —
Özet
Transbronşial biopsi örneklerinde M. tuberculosis, immunojenikprotein MPB64 geni polimeraz zincir reaksiyonuyla araştırılan altı hasta sunuldu. PCR'la altı örneğin üçünde M. tuberculosis DNA 'sı belirlendi. Sarkoidozlu hastalar on yıl izlendi. Polimeraz zincir reaksiyonuyla M. tuberculosis pozitif ve negatif hastaların tüberkülin test sonuçları ve klinik yönü tartışıldı. Klinik yönü ve mikobakteriyel DNA pozitifliği arasında ilişki olmadığına karar verildi.
Abstract
We present six patients with sarcoidosis whose transbronchial biopsy specimens had been investigated, the gene of immunogenic protein MPB64 for Mycobacterium tuberculosis by polymerase chain reaction analysis. M. tuberculosis DNA was detected in three of them by PCR. We followed patients with sarcoidosis for ten years. We discussed tuberculin test results and clinical course of M. tuberculosis positive and negative patients with polymerase chain reaction. we cannot make a conclusion about a relationship between clinical course and mycobacterial DNA positivity.