Dergiler / Turkish Journal of Pharmaceutical Sciences / 2007 / Cilt: 4 - Sayı: 2
Evaluation of anti-inflammatory and antinociceptive activity of five Anatolian Achillea species
- Sayfa
- 89–100
- DOI
- —
Özet
Achillea türleri Türkiye’de halk arasında, anti-enflamatuvar, analjezik, spazmolitik, hemostatik, dijestif ve kolagog etkilerinden dolayı kullanılmaktadır. Folklorik kullanımı değerlendirmek amacıyla, beş Achillea türünün “Achillea wilhelmsii C.Koch, A. setacea Waldst&Kit, A. vermicularis Trin., A. phrygia Boiss.&Bal. and A. sipikorensis Hausskn. et Borm.” antinonsiseptif ve anti-enflamatuvar aktiviteleri çalışıldı. Antinosiseptif aktivite için p-benzokinon nedenli kıvranma testi, anti-enflamatuvar aktivite için karragen-nedenli arka ayak ödemi testi uygulandı. A. wilhelmsii, A. setacea ve A. vermicularis’ten hazırlanan etanollü ekstre 500 mg/kg dozda herhangi bir akut toksisite ve gastrik hasar oluşturmaksızın kuvvetli antinosiseptif ve anti-enflamatuvar aktivite gösterdi. A. phrygia sadece kuvvetli antinosiseptif aktivite gösterirken A.sipikorensis herhangi bir anti-enflamatuvar ve antinosiseptif aktivite göstermedi.
Abstract
Achillea species have been used for their anti-inflammatory, analgesic, spasmolytic, hemostatic, digestive and cholagogue effects in Turkish folk medicine. In order to evaluate their folkloric utilization, both antinociceptive and anti-inflammatory activities of five Achillea species including Achillea wilhelmsii C.Koch, A. setacea Waldst&Kit, A. vermicularis Trin., A. phrygia Boiss.&Bal. and A. sipikorensis Hausskn. et Borm. were investigated. For the antinociceptive activity, p-benzoquinone-induced writhing test and for the anti-inflammatory activity, carrageenan-induced hind paw edema model in mice were employed. The ethanol extracts of A. wilhelmsii, A. setacea and A. vermicularis showed significant antinociceptive and anti-inflammatory activity at 500 mg/kg dose, per os, without inducing any apparent acute toxicity as well as gastric damage. A. phrygia was shown to possess only significant antinociceptive activity, on the other hand A. sipikorensis did not show any remarkable anti-inflammatory and antinociceptive activity.