Dergiler / Turkish Journal of Pharmaceutical Sciences / 2005 / Cilt: 2 - Sayı: 1
Synthesis and antimicrobial activity of some new mannich bases of 7-acyl-5-chloro-2-oxo-3H-benzoxazole derivatives
- Sayfa
- 25–33
- DOI
- —
Özet
7-Acil-5-Kloro-2-Okso-3H-Benzoksazollerin mannich bazları, bu türevlerin formaldehit ve birkaç sekonder amin türevleriyle tepkimeye sokulmasıyla sentezlenmiştir. Kimyasal yapıları, İR, H-NMR ve elementel analiz verileriyle kanıtlanmıştır. Bileşiklerin in vitro antimikrobiyal aktivitelerinin incelenmesi, altı patojenik bakteriye karşı broth mikrodilisyon yöntemi kullanılarak yapılmıştır.
Abstract
A series of novel Mannich bases of 7-acyl-5-chloro-2-oxo-3H-benzoxazoles were synthesized by reacting them with formaldehyde and several seconder amine derivatives. Their chemical structures were elucidated by means of their IR, 'H-NMR data and by elemental analysis. Investigation of in vitro antimicrobial activity of compounds was done by broth microdilution method against six pathogenic bacteria.