Evaluation of antimicrobial activity of 2-(2-NITRO-1-phenylalkyl) thiomethyl) benzimidazole derivatives

2-(2-Nitro-1-fenilalkil)tiyometil)benzimidazol türevlerinin antimikrobiyal aktivitesinin değerlendirilmesi

Özet

Bu çalısmada sekiz 2-[(2-nitro-l-feniletil)tiyometil]benzimidazol (la-h) ve clokuz 2-[(2-nitro-l- fenilpropil)tiyometil]benzimidazol (2a-i) türevlerinin antifungal ve antibakteriyel aktiviteleri test edilmiştir. Bileşiklerin minimum inhibisyon konsantrasyon değerleri Gram-pozitif, Gram-negatif bakterilere ve maya benzeri mantarlara karsi mikrodilüsyon metodu kullandarak test edilmiştir. Bileşik (2h) ve (21) Staphylococcus aureus ve Streptococcus faecalis ’e karsi ampisilin trihidrat kadar aktif bulunmuştur. Bileşik (la) ketokonazole yakın antifungal aktivite göstermiştir.

Abstract

In this study eight 2-[(2-nitro-1-phenylethyl)thiomethyl]benzimidazole (1a-h) and nine 2-[(2-nitro-1- phenylpropyl)thiomethyl]benzimidazole (2a-i) derivatives were tested for their antibacterial and antifungal activities. The minimum inhibition concentration (MIC) values of the compounds were tested by the microdilution method against Gram- positive, Gram-negative bacteria and yeast like fungi. Compounds (2h) and (2i) were found to be active as ampicillin trihydrate against Staphylococcus aureus and Streptococcus faecalis, (4.80x10-3 , 4.80x10-3 and 5.20x10-3,5.20x10-2 and 4.80x10-3, 4.80x10-3 µM respectively). Compound (1a) has showed antifungal activity close to Ketoconazole (1.05x10-3 and 0.90x10-3µM respectively).