Dergiler / Turkish Journal of Pharmaceutical Sciences / 2011 / Cilt: 8 - Sayı: 1
Synthesis, characterization and anti-bacterial activity of certain 2,3,4,5-tetrahydropyridazinone analogues
- Sayfa
- 71–80
- DOI
- —
Özet
Bu gahsmada; altı yeni Piridazinon tiirevleri sentezlenmiş ve antibakteriyel aktiviteleri değerlendirilmiştir. Deneysel gahsmamız sırasıyla, benzoil propiyonik asit (a), 6-fenil-2,3,4,5,-tetrahidro piridazin-3-on (b) ve daha sonra geşitli aldehitlerle ilgili tiirevlerinin sentezlenmesini igermektedir. Turn sentezlenmiş olan bileşiklerin yapılan IR ve HNMR teknikleri He tayin edilmiştir. Uaveten Staphylococcus aureus (MTCC 737), Staphylococcus epidermidis (MTCC 3615), Pseudomonas aeruginosa (MTCC 424) ve Escherichia coli (MTCC 1687) kullamlarak sentezlenen bileşiklerin antimikrobiyal aktiviteleri tespit edilmiştir.
Abstract
In the present study, six new derivatives of Pyridazinone were synthesized and evaluate their anti-bacterial activity. The experimental work involves the synthesis of benzoyl propionic acid (a), then 6-pheny1-2,3,4,5-tetrahydro pyridazin-3-one (b) which was then condensed with various aldehydes to form respective derivatives. All the synthesized compounds were identified by IR, 'HNMR and antimicrobial activity was performed on the compounds synthesized against Staphylococcus aureus (MTCC 737), Staphylococcus epidermidis (MTCC 3615), Pseudomonas aeruginosa (MTCC 424) and Escherichia coli (MTCC 1687).