The relationship between monocyte HDL-C ratio and reduced left ventricular systolic function in patients among acute myocarditis

Özet

Myocarditis contributes to the global burden of cardiovascular disease mainly through sudden death and chronic cardiomyopathy in young age groups. Monocyte/high-density lipoprotein cholesterol (HDL-C) ratio (MHR) has developed as a new inflammation biomarker. In this study has investigated that relationship between ad-mission MHR levels and the reduced left ventricular systolic functions after acute myocarditis. The study included a total of 156 consecutive cases wanted by their doctors to undergo cardiovascular magnetic resonance imaging for “acute myocarditis” as the clinical diagnosis between 2009 and 2017 at our hospital. Study participants were split into two groups; group I patients (patients with LVEF <40%), group II patients (patients with LVEF ≥40%) at last follow-up visit. 13 case had reduced left ventricle systolic function (LVEF <40%) at their last follow-up visit. MHR was significantly higher in the group-I (P <0.05). A level of 14.6 for MHR showed an association with reduced in left ventricular systolic function with 84% sensitivity and 76% specificity. Multivariate logistic regression analyses showed that high MHR were significantly associated with reduced left ventricle systolic functions (for all; p <0.05). MHR had a significantly positive correlation with CRP level in the correlation tests (r = 0.356; p <0.001). We presented admissions MHR levels of the with cases after acute myocarditis with reduced left ventricle systolic functions were significantly higher than cases with normal left ventricle systolic functions. This parameter may be utilized to estimate worse clinical endpoints in patients with acute myocarditis.