Correlation between Psoriasis and ZIP2 and ZIP3 Zinc Transporters

Özet

ZIP2 is associated with keratinocyte differentiation, whereas ZIP3 is associated with T-lymphocyte maturation. In our study, we aimed to showthe correlation between psoriasis and ZIP2 and ZIP3 zinc transporters in psoriasis patients. Subjects and Methods: The patient group in thestudy included 60 patients aged with psoriasis vulgaris and a control group of 60 healthy adults. The levels of ZIP2 (SLC39A2) and ZIP3(SLC39A3) zinc transporters were determined with the ELISA method. Results were compared with control group values and statisticallyassessed. Results: When the ZIP2 and ZIP3 levels are compared in controls and psoriasis patients, the levels were observed to significantlyincrease compared to controls (P < 0.05). When compared to the control group, the results appeared to be statistically significant (P < 0.05).Conclusions: With etiopathogenesis not fully known, there may be an important relationship between psoriasis development and ZIP2(SLC39A2) and ZIP3 (SLC39A3) zinc transporters in psoriasis vulgaris patients. This situation may be an important result for understandinghow the disease develops and in creating new approaches in terms of treatment for this disease without full cure available.