Evaluation of early and late-term infections after renal transplantation: Clinical experiences of Sanko University Medical Faculty Transplantation Center

Özet

Objective: Infections play an important part in post-transplantation causes of morbidity and mortality. Thepurpose of this study is to evaluate short-, and long-term infections encountered in after renal transplantations.Material and methods: Two hundred and thirteen cases that consisted of both living and cadaver donors,who suffered from late period renal insufficiency and had renal transplant between June 2011 and January2016 at the Transplantation Center of Sanko University School of Medicine were included in the study. Inthis study the short-, and long-term infections seen in post renal transplantation were examined retrospectively. Infection types, frequency and periods of infection, infection agents and predisposing factors weredetermined as the examination parameters.Results: Of the 213 patients who received renal transplant, 139 were males (65.3%) and 74 were women(34.75%) and the mean age was 42±11,8 (range, 14-70) years. Twelve (5.6%) patients exited after renal transplantation. Post-transplant infections were seen in 49 patients (23.1%) within 1-6 months; in 13 patients(6.1%) within 6-12 months; and in 5 patients (2.4%) after the 12th month. The most common infections afterrenal transplantation were associated with urinary tract (70 patients, 34.3%). The most frequently isolatedagents were E. coli (n=66; 30.9%), Kebsiella spp. (n=18; 8.4%) and Enterococci (n=18; 8.4%) respectively.The renal transplants from the cadavers were observed to contract infections 1.78 times more frequentlycompared to the living donors (OR=1.78, 95% CI=1.03-3.09).Conclusion: The most common complication after renal transplantation are infections. The majority of theinfections are seen within the first year especially between 1-6 months. Post-transplant infections are oftenrelated to urinary system. E.coli is the most frequently isolated agent and it may be responsible for urosepsisin renal transplant patients. Infection more often seen in renal transplantations from cadavers.