Effects of different intraabdominal pressure levels on oxidative stress markers in laparoscopic cholecystectomy

Özet

Objective: To evaluate the effect of laparoscopic cholecystectomy performed under different intraabdominal pressure on oxidative stress markers.Material and Methods: This prospective, randomized, controlled study examined 90 consecutive healthy patientswho underwent elective laparoscopic cholecystectomy with the diagnosis of symptomatic cholelithiasis. The patients were divided into three groups, 30 patients in each. Group 1 included patients who underwent laparoscopiccholecystectomy at a CO2 pneumoperitoneum pressure of 7 mmHg, Group 2 patients who underwent laparoscopiccholecystectomy at a CO2 pneumoperitoneum pressure of 10 mmHg, and Group 3 patients who underwent laparoscopic cholecystectomy at a CO2 pneumoperitoneum pressure of 13 mmHg. Blood samples were collected preoperatively, perioperatively, and postoperatively for measurement of the serum levels of ischemia modified albumin andan analysis of total antioxidant status and total oxidant status. Intra-group comparisons were made.Results: Group 1 experienced a significant increase in the postoperative ischemia modified albumin values compared to preoperative ischemia modified albumin values (p=0.013). Group 2 experienced a significant decreasein the perioperative total antioxidant status values compared to preoperative and postoperative total antioxidantstatus values (p=0.009). Group 3 experienced a significant increase in the perioperative total oxidant status andoxidative stress index values compared to preoperative values (p<0.001). Group 3 experienced a significant increase in the perioperative and postoperative ischemia modified albumin values compared to preoperative values(p<0.001).Conclusion: Increased levels of oxidative stress markers were detected in patients who underwent laparoscopiccholecystectomy at a high intraabdominal pressure level.