Dergiler / Turkish Journal of Rheumatology(.)Archives of Rheumatology / 2013 / Cilt: 28 - Sayı: 4
An Evaluation of Mean Platelet Volume and Serum Lipid Profile in Patients with Fibromyalgia Syndrome
- Sayfa
- 251–255
- DOI
- —
Özet
Amaç: Bu çalışmada fibromiyalji sendromlu (FMS) hastalarda ortalama trombosit hacmi (OTH) ve serum lipid profili değerlendirildi.Hastalar ve yöntemler: Bu retrospektif çalışma, Ocak 2011 - Aralık 2011 tarihleri arasında üç merkeze başvuran 156 FMS hastası ve 118 sağlıklı kontrolden oluşuyordu. Hastaların açlık kan glukoz, total kolesterol, düşük yoğunluklu lipoprotein (LDL) ve yüksek yoğunluklu lipoprotein (HDL) kolesterol, trigliserid düzeyleri ve tam kan sayımı ve OTH değerleri kaydedildi. İstatistiksel analiz için verilerin dağılım yapısına göre Mann-Whitney U testi ve Student t-test kullanıldı.Bulgular: Çalışmanın etki büyüklüğü 0.6 iken deneysel gücü, %100 (0.00063) olarak hesaplandı. Ortalama trombosit hacmi, hasta grubunda 8.75±1.15 fL; sağlıklı kontrollerde 8.13±0.73 idi (p<0.001). Trigliserid düzeyleri, sağlıklı kontrollere kıyasla, FMS hastalarında anlamlı düzeyde artmıştı (p=0.003).Sonuç: Fibromiyalji sendromlu hastalarda aterosklerozun erken belirteçlerinden biri olan OTH'nin anlamlı düzeyde yüksek olduğu belirlendi.
Abstract
Objectives: This study aims to evaluate the mean platelet volume (MPV) and serum lipid profile in patients with fibromyalgia syndrome (FMS). Patients and methods: This retrospective study was comprised of 156 patients with FMS and 118 healthy controls who were admitted to three centers between January 2011 and December 2011. The patients' fasting blood glucose, total cholesterol, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol, triglyceride levels and complete blood count, and MPV values were recorded. The Mann-Whitney U test and Student's t-test were used according to the distribution of the data for statistical analysis. Results: The experimental power of the study was found to be 100% (0.00063), when the effect size was taken as 0.6. The MPV value was 8.75±1.15 fL in the patient group and 8.13±0.73 in the healthy controls (p<0.001). The serum triglyceride levels were significantly increased in the patients with FMS compared with the healthy controls (p=0.003). Conclusion: We found that the MPV, one of the early markers of atherosclerosis, was significantly high in the FMS patients.