New Bio-Markers: Cell-Free DNAs and MICRO-RNAs

Özet

The only reason of being in the same review of cell free DNAs (cfDNA) and micro–RNAs (miRNA) , whose only commonpoints were being tiny, showing up in the circulation and their visibility that can be increased by amplifications, is that;both of them quickly entered the research and clinical world as candidates of bio-markers for diagnosis and follow-up formany diseases with considerable number of studies published since last two decades, cfDNAs can be found in the circulation as a steady signature of a given diseased condition while miRNAs are found both as a steady marker of a disease, anda transmitter of a malign behavior into the intact cells. In our review, we tried to briefly explain the biogenesis of both andtheir relationship with diseases and their clinical uses. The idea that cfDNAs and miRAs can be used as a diagnostic andfollow-up criterion in transplantation is a new approach. Transplant practice has long been in search of new laboratorymethods that can allow for the early detection of rejection without any clinical symptoms. The early studies on the use ofcfDNA and miRNAs in post- transplant monitorization indicate that both are promising candidates as bio-markers.