Time to Prevent the Development of Diabetic Nephropathy

Özet

The consistent increase in the incidence of diabetes and its complications represents an obsession of health care providers worldwide. Diabetic nephropathy is responsible for nearly half of the chronic kidney diseases. The morbidity and mortality rates of diabetes patients admitted to dialysis is much higher than non-diabetic cases. These facts are behind the tremendous efforts undertaken to understand the pathogenesis and therapeutic modalities of this disease. Over the last four years, a plethora of data has evolved to revive the hope not only to slow the rate of progression of this disease but possibly to prevent its evolution. In this review, we are going to discuss the most relevant and novel pathogenic mechanisms of diabetic nephropathy and the most suitable approach to prevent its development.