Association of Proton Pump Inhibitors Use and Renal Functions in Elderly

Özet

Introduction: Recently, side effects and especially renal effects of proton pump inhibitors have been pronounced more frequently. It is thought that they may lead to clinical situations as acute tubulointerstitial nephritis, acute kidney injury and progression of chronic kidney injury. In this study, we investigated the frequency of proton pump inhibitor use and its association with proteinuria and kidney injury in older patients admitted to our nephrology outpatient clinic. Methods: The medical records of patients aged 75 years and older who applied to the nephrology outpatient clinic for a period of one year were examined.Results: The frequency of proton pump inhibitors use is high in our 75 years and older patients admitted to the nephrology outpatient clinic. In elderly patients using proton pump inhibitors, the association with chronic kidney injury was found to be more frequent, although not statistically significant.Conclusion: Unaware and/or off-label use of proton pump inhibitors may be associated with impaired renal function. Renal functions should be monitored in patients who have to use a proton pump inhibitor.