Effects of Alprazolam and Melatonin Used for Premedication on Oxidative Stress, Glicocalyx Integrity and Neurocognitive Functions

Özet

Objective: The purpose of this investigation was to compare the effect of alprazolam and melatonin on oxidative stress, glicocalyx integrityand neurocognitive function in patients undergoing coronary artery bypass grafting (CABG).Methods: Overall, 42 patients undergoing CABG were retrospectively included in this study. Blood samples which preserved at −70°C for aprevious study were used for this study. The participants were divided into two groups. Patients in the Group A were administered alprazolambefore the operation, whereas melatonin was used for premedication in the Group M. Blood samples were collected at three time points [T0:before anaesthesia induction, T1: admittance to intensive care unit (ICU), T2: 24 h after ICU admission], and oxidative stress parametersand glicocalyx integrity were evaluated. Furthermore, Mini-Mental State Examination was recorded to measure neurocognitive function.Results: The total thiol levels which were measured as an antioxidant parameter were significantly higher, and free Hb values were significantlylower in the Group M compared to the Group A (p 0.05).Conclusion: In light of positive effects on oxidatif stress parameters, melatonin may be considered as a good and safe premedication agentwith its anxiolytic, antioxidant and minimal haemodynamic and respiratory effects.