Palonosetron Pretreatment is not as Effective as Lignocaine for Attenuation of Pain on Injection of Propofol

Özet

Objective: 5-HT3 receptor antagonists are known to possess local anesthetic properties and are commonly used for the alleviation of painfollowing propofol injection. Palonosetron, a newer molecule, has shown contradictory results for this property. The aim of this study was to compare the effect of palonosetron pretreatment in alleviating propofol injection pain with that of lignocaine. Their comparative effect on varioushemodynamic parameters was also evaluated.Methods: A total of 100 adult patients were randomly assigned to one of two groups: group L received lignocaine 40 mg in 5 mL of 0.9% salinepretreatment solution and group P received 0.075 mg palonosetron in 5 mL 0.9% of saline pretreatment solution. After 2 minutes, the tourniquetwas released and one-fourth of the total calculated dose of propofol was administered, after which the pain assessment was made. The Studentst-test was used for comparing the difference of mean between the two groups after testing for equality of variance using F-statistics. Categoricalvariables were expressed as a percentage, and the Chi-square test was performed to assess the independence of attributes. Repeated-measureanalysis of variance was used to compare the change in heart rate and mean arterial pressure over three time points between the two groups.Results: The proportion of pain reported by the subjects in the lignocaine group was significantly lower as compared to the subjects in thepalonosetron group (p=0.001). No significant difference of mean heart rate and mean arterial pressure was observed between the two groupsfollowing these interventions.Conclusion: The efficacy of palonosetron in alleviating the pain on injection of propofol was significantly less than that of lignocaine.