Investigation of the Protective Effect of Nigella Sativa Oil in Cisplatin Induced Oral Mucositis: An Experimental Study

Özet

Objective: The aim of this experimental study was toinvestigate the histopathologic effect of Nigella Sativaoil (NSO) on cisplatin (Cis) induced oral mucositis(OM) in rats.Methods: Twenty-four rats were divided into fourequal groups. The animals in Group 1 and Group 2were given 5 mg/kg intraperitoneal (ip) Cis systemically on the 1st, 3rd and 5th days of the study. Additionally, 15 mL NSO were given to the rats in Group2, with gavage feeding on days 1, 3, 5, 7, and 9. Theanimals in Group 3 were given per oral 15 ml NSOon days 1, 3, 5, 7 and 9. As the control group, Group 4received a total of 15 mL 0.9% saline solution dividedinto 5 doses on days 1, 3, 5, 7 and 9 by oral gavage.On the 14th day, animals were euthanized and buccalmucosa from both sides, including submucosal tissues,were excised and taken to histopathological examination.Results: The mean mucosal thicknesses of the groupswere 224.58 µm, 276.1 µm, 323.33 µm, and 331.33 µm,respectively for Groups 1, 2, 3, and 4 (p 0.05).Conclusion: According to the results of this study,NSO, for which anti-inflammatory and antioxidantproperties have been shown in previous studies, mayalso be effective in preventing Cis-induced OM.