Angiogenesis and endothelial markers in primary CNS tumors

Abstract

The neovascularization and endothelial antigenic changes of 47 different types of central nervous system tumors were analyzed • histochemically and immunohistochemically. The relation between the endothelial antigenic characteristics and the histological grading was also examined. Vascular endothelial proliferation was detected in the reticulum stain. Immunohistochemically, factor VIM related antigen (FVIIIR:Ag) and blood-group isoantigens (BGAg) were used as endothelial markers. In all the examined sections a diffuse, linear or slightly granular immunostaining pattern was observed in the endothelium for both antigens. The distribution and intensity of the antigens were nonspecific among the grades. [Turk J Cancer 1995;25(3):i11-9]