The relation between intensity and complexity of coronary artery lesion and oxidative stress in patients with acute coronary syndrome

Özet

Objective: Oxidative stress plays a major role in the development of atherosclerosis. However, the relationship between oxidative stress andcomplexity and intensity of coronary artery disease is less clear. The aim of this study is to assess the relationship between oxidative stressmarkers and the complexity and intensity of coronary artery disease in patients with acute coronary syndrome (ACS).Methods: Sixty-seven consecutive patients with an early phase of ACS ( =22). Likewise patients were divided into twoCAD severity groups according to the median Gensini score of 64: less intensive CAD with Gensini score ( =64. Blood samples were taken in 1 hour within administration in order to measure total oxidative status (TOS) and total antioxidantcapacity (TAC) levels determined by Erel method. Oxidative stress index (OSI) was calculated by TOS /TAC.Results: There was no significant difference between the two SYNTAX groups for oxidative stress markers. Median TOS and OSI values were significantly highin the intensive CAD group (p=0.005, p=0.04, respectively). The Gensini score was positively correlated with TOS and OSI (p=0.003, p=0.02, respectively).Conclusion: Oxidative stress markers may be considered supportive laboratory parameters related to CAD intensity but not complexity in ACSpatients. (Anatol J Cardiol 2015; 15; 795-800)Keywords: acute coronary syndrome, oxidative stress, coronary artery disease, total antioxidant capacity, total oxidative stress, oxidative stressindex, myocardial infarction