The effect of experimental hypothyroidism on nasal mucosa

Abstract

Objectives: This study aims to investigate the histopathological changes in nasal mucosa and alterations in thyroid hormone receptors in an experimental postnatal hypothyroidism model. Materials and Methods: Twenty-one Wistar albino newborn rats born from the pregnant rats were enrolled in this prospective randomized study and were divided into two groups: Group 1 n=11, methimazole, MMI -induced hypothyroidism group given MMIwater, and Group 2 n=10, control group , normal tap water. When the offspring reached 90 days, they were decapitated and the nasal mucosa was removed. Thyroid hormone receptor TR-a, TR-b status was assessed by immunohistochemical staining. Results: The difference between hypothyroidism and control groups regarding inflammation was statistically significant p